Biophysics of pulsatile perfusion

Effect of pulsatile flow perfusion on decellularization

BACKGROUND Decellularized animal organs have been used as scaffolds for tissue engineering. To make a properly functioning scaffolds, the extracellular matrix (ECM) components must be preserved after decellularization. Because pulsatile flow is known to be beneficial for tissue perfusion, pulsatile perfusion of a detergent might decrease the exposure time of the tissues to the detergent used fo...

Effects of pulsatile perfusion upon left ventricular function.

This study compares the effects of pulsatile and nonpulsatile perfusion upon myocardial contractility. After 2 hr of ventricular fibrillation, control animals demonstrated a 37% decrease in left ventricular force, a 48% decrease in left ventricular compliance, and an increase in endomyocardial water content. On the other hand, after 2 hr of ventricular fibrillation, animals undergoing pulsatile...

Clinical comparison of pulsatile and nonpulsatile perfusion during cardiopulmonary bypass.

Controversy exists concerning the utilization of pulsatile flow during cardiopulmonary bypass (CPB) with regard to improved patient outcomes. The purpose of the present study was to evaluate pulsatile perfusion in patients undergoing CPB in a clinical setting. Seventy patients undergoing open heart surgery for repair of valvular or congenital heart disease were prospectively entered into the st...

Biophysics.

A paired study comparing the efficacy of renal preservation by normothermic autologous blood perfusion and hypothermic pulsatile perfusion.

THE REDUCTION in metabolic rate effected by hypothermia constitutes the central tenet of traditional organ preservation. The antithesis of this approach is to provide for metabolic demand during normothermic preservation. This latter strategy has two potential benefits. First, if metabolic requirements are met during preservation, then longer preservation with better posttransplant function may...